منابع مشابه
Microtubule-severing enzymes at the cutting edge.
ATP-dependent severing of microtubules was first reported in Xenopus laevis egg extracts in 1991. Two years later this observation led to the purification of the first known microtubule-severing enzyme, katanin. Katanin homologs have now been identified throughout the animal kingdom and in plants. Moreover, members of two closely related enzyme subfamilies, spastin and fidgetin, have been found...
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Katanin is a conserved AAA ATPase with the ability to sever microtubules, but its biological function in animal cells has been obscure. A recent study using electron tomography has found that katanin stimulates the production of microtubules in the meiotic spindles of Caenorhabditis elegans oocytes.
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arly endosomes may help to create their own short-range tracks, according to a report from Stéphane Gasman, Yannis Kalaidzidis, and Marino Zerial (Max Planck Institute, Dresden, Germany). The results also suggest parallels between membrane trafficking, signaling, and regulation of the cytoskeleton. Trafficking of early endosomes requires the small GTPase RhoD. Zerial’s group identified the firs...
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he democratization of journalism through crowd sourcing, blogging, and social media has proven to be a sharp, double-edged sword. The internet has vastly expanded the sourcing of news and information, capturing stories that might otherwise go untold and delivering a diversity of perspectives that no single media outlet could hope to offer. At the same time, this new and open model has given any...
متن کاملTubulin polyglutamylation stimulates spastin-mediated microtubule severing
Posttranslational glutamylation of tubulin is present on selected subsets of microtubules in cells. Although the modification is expected to contribute to the spatial and temporal organization of the cytoskeleton, hardly anything is known about its functional relevance. Here we demonstrate that glutamylation, and in particular the generation of long glutamate side chains, promotes the severing ...
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ژورنال
عنوان ژورنال: Nature Reviews Microbiology
سال: 2010
ISSN: 1740-1526,1740-1534
DOI: 10.1038/nrmicro2458